Perfom structure-activity of the structure of alpidem. SAR analysis as in the example below

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Perfom structure-activity of the structure of alpidem. SAR analysis

Perfom Structure Activity Of The Structure Of Alpidem Sar Analysis As In The Example Below 1 (23.13 KiB) Viewed 39 times

as in the example below

Perfom Structure Activity Of The Structure Of Alpidem Sar Analysis As In The Example Below 2 (22.73 KiB) Viewed 39 times

Perform structure activity identification (SAR) of alpidem that has the estructure. H₂C -CH₂ CI
1-NR group is optimal for activity R Effects of ring A on activity: Aromatic ring heteroaromatic ring -EWG required electronegativity the activity A L 6' in in B 3 N 4 2 H-accepting group ↑ the activity 2-C-O group is importanty for activity 1,2-fused trazole or imidazole ring the activity B substitution with a 3-OH group the activity w/ 3-OH group: polar, readly converted to the excreted glucuronide →↓ DOA w/o 3-OH group: nonpolar, undergo hepatic oxidation & active metabolite DOA 5-phenyl group ↑ activity 2 or 2. 6 substituted with EWG activity 4' substitution activity