A 50-year-old man comes to the physician because of a persistent cough for the past 2months. He has had a 5-kg (11-lb) w

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A 50-year-old man comes to the physician because of a persistent cough for the past 2months. He has had a 5-kg (11-lb) weight loss during this period. He is a farmer and started itraconazole therapy 4 weeks ago for histoplasmosis acquired after contact with chicken coops. Current medications also include hydrochlorothiazide, enalapril, atenolol, omeprazole, and metoclopramide for hypertension and gastroesophageal reflux. He appears thin. Physical examination shows no other abnormalities. An interaction between itraconazole and which of the following drugs most likely accounts for the lack of effect of itraconazole?

A) Atenolol
B) Enalapril
C) Hydrochlorothiazide
D) Metoclopramide
E) Omeprazole