Experiment 2 6 As Protection Of A Primary Amine Micro Scale Synthesis Of 2 Hydroxyphenylphthalamide Introduction Amin 1 (54.04 KiB) Viewed 91 times
Experiment 2 6 As Protection Of A Primary Amine Micro Scale Synthesis Of 2 Hydroxyphenylphthalamide Introduction Amin 2 (54.04 KiB) Viewed 91 times
Experiment 2.6 AS Protection of a Primary Amine- Micro-scale Synthesis of 2- Hydroxyphenylphthalamide Introduction: Amines are exceedingly important compounds, not only to the organic chemist, but in life. In the fon amino acids, amines are the building blocks of life itself. Peptides and proteins are polymers of amino ac a dipeptide containing two amino acid residues, a tripeptide containing three, etc. A protein is a polypept which can be made from 40 to 4000 amino acid residues. The lone pair of electrons of the nitrogen atom cause amines to react as bases, sharing their lone pair with proton, to react as nucleophiles, sharing their lone pair with an atom other a proton. Because of this, amine at a highly reactive species, reacting with alkyl halides, acid chlorides, aldehydes and ketones. Sometimes, it becomes necessary to protect an amine in order to prevent it becoming involved in a reaction. This allows other functional groups to react without the mine interfering. There are several ways to protect an amine/amino acid. One way is to react the mine with phthalic anhydride in acetic acid to form aplitimde + - HO оно Procedure: Baca acetic acid Wed 0.370g (370mg, 2.5 mmol) phthalic anhydride and transfer to a clean dry BIO Sem round bottomed Dusk along with 2 anti-bumping granules. Using a plastic Pasteur pipette, carefully add 2.5cm of concentrated Weight 0.273g (273mg, 2.5 mmol) 2-aminopherol and also transfer to the reaction flask Fita B10 micro Tedense and using a sand bath and thermostatically controlled hot plate, (adjusted to 125 C, maintain y reflux for about 1 hour. Allow the reaction mixture to cool toron lemperature before opaling father ce precipitation does not occur at this point slowly add ice-cold tap water to aid the procese Vacuum for the crade product material and wash the precipitate with Sem of ice-cold water followed by 3xOS Shuts of ice cold pet ether 40-60. A small adequate of ice-cold water may be used to help with the transfer se geoduct mix from the reaction vessel to the filer funnel All the crude product to air dry at the vacuum before recording the yield and melting point 89
Join a community of subject matter experts. Register for FREE to view solutions, replies, and use search function. Request answer by replying!