A 36-year-old man was found to have hypercholesterolemia. A dietary evaluation indicated that he was consuming about 6

[answerhappygod]

A 36-year-old man was found to have
hypercholesterolemia. A dietary evaluation indicated
that he was consuming about 600 mg/day of cholesterol. His
plasma concentration on two separate occasions was approximately
330 mg/dl. Ultracentrifugal analysis revealed that the
cholesterol elevation was due to an increase in plasma LDL.
He was treated with a cholesterol-free vegetarian diet for 3
months, but his plasma cholesterol level decreased to only 300
mg/dl. Subsequently, he was treated with colestipol-HCl, bile
acid-binding resin that is not absorbed. The resin binds bile
acids, causing increased amounts to be excreted in the feces.
This treatment lowered the fasting plasma cholesterol concentration
to 250 mg/dl.
Discuss this case by applying the cholesterol absorption,
transport, and metabolic pathways and answer the following
questions
1. How is dietary cholesterol absorbed?
2. How is it possible for a patient to continue to have high
plasma cholesterol after being on a cholesterol-free diet for
3 months?
3. What connection is there between bile acids and
cholesterol?
4. How does a bile acid-binding resin (fiber) lower the plasma
cholesterol concentration?
5. Would you combine this drug with statins? If yes what
is the benefit?