Describe the chemistry of doripenem (Doribax©) and explain how its structure confers antimicrobial activity. In comparis

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Describe the chemistry of doripenem (Doribax©) and explain how its structure confers antimicrobial activity. In comparis

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Describe the chemistry of doripenem (Doribax©) and
explain how its structure confers antimicrobial activity. In
comparison to amoxicillin, outline the unique chemical features of
doripenem.
The New Delhi metallo-β-lactamase
(NDM-1) from K. pneumoniae
is highly efficient in the inactivation of doripenem.
Briefly discuss the properties of NDM-1 and the mechanism of
doripenem inactivation. (10
marks)
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